Water → 2-Chloro-5-[3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidinyl]benzaldehyde

Participants

Reaction Steps

5 ml of water were added to a solution of 1.9 g of 3-(4-chloro-3-(1,3-dioxolan-2-yl)-phenyl)-2,4-dioxo-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine in 45 ml of glacial acetic acid. After stirring had been carried out for 12 hours at about 20-25° C. and for a further 5 hours at 40-50° C., 150 ml of water were stirred into the mixture. Thereafter, the precipitate formed was isolated, washed with water and petroleum ether and dried.

Provenance & Evidence