2,3-Butanediol → 3-[4-Chloro-3-(4,5-dimethyl-1,3-dioxolan-2-yl)-phenyl]-2,4-dioxo-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine

HRID 1978851Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1978851
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:13](=[O:14])[CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[N:10]([CH3:19])[C:9]2=[O:20])=[CH:4][C:3]=1[CH:21](OC)OC.[OH:26][CH:27]([CH:29]([OH:31])[CH3:30])[CH3:28].C1(C)C=CC(S(O)(=O)=O)=CC=1.O>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:13](=[O:14])[CH:12]=[C:11]([C:15]([F:16])([F:18])[F:17])[N:10]([CH3:19])[C:9]2=[O:20])=[CH:4][C:3]=1[CH:21]1[O:31][CH:29]([CH3:30])[CH:27]([CH3:28])[O:26]1

Komponenten

6

Edukt 4

HCID 2622,3-ButanediolHCID 962WaterHCID 6101p-Toluenesulfonic acidHCID 212012303-(4-Chloro-3-dimethoxymethylphenyl)-2,4-dioxo-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine

Produkt 1

HCID 212012333-[4-Chloro-3-(4,5-dimethyl-1,3-dioxolan-2-yl)-phenyl]-2,4-dioxo-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

30 g of 3-(4-chloro-3-dimethoxymethylphenyl)-2,4-dioxo-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine, 2.1 g of 2,3-dihydroxybutane and 0.3 g of p-toluenesulfonic acid were dissolved in 100 ml of anhydrous toluene, and the stirred solution was refluxed for 7 hours in the absence of water. For working up, the solution was washed in succession with water and 10% strength NaHCO3 solution, dried over Na2SO4 and evaporated down.

Aufarbeitung

  1. washthe solution was washed in succession with water and 10% strength NaHCO3 solution
  2. dry with materialdried over Na2SO4
  3. customevaporated down

Quellen und Nachweise

ORD-Eintrag
ord-7d6e3cacd3c947e8ad253148ce189de9
Quelldatensatz
uspto-grants-2001_05
Patentnummer
US06239074B1

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