反应详情

30 g of 3-(4-chloro-3-dimethoxymethylphenyl)-2,4-dioxo-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine, 2.1 g of 2,3-dihydroxybutane and 0.3 g of p-toluenesulfonic acid were dissolved in 100 ml of anhydrous toluene, and the stirred solution was refluxed for 7 hours in the absence of water. For working up, the solution was washed in succession with water and 10% strength NaHCO3 solution, dried over Na2SO4 and evaporated down.

1. washthe solution was washed in succession with water and 10% strength NaHCO3 solution
2. dry with materialdried over Na2SO4
3. customevaporated down