反应详情

19.4 g of methyl 4-aminothiophen-3-carboxylate hydrochloride were added to a suspension of 7.7 ml of thiophosgene and 18.5 g of sodium bicarbonate in 70 ml of water and 200 ml of dichloromethane at room temperature in the course of 30 minutes, and stirring was carried out for 1 hour at room temperature. After separation of the phases, the aqueous phase was extracted once with dichloromethane and the combined organic phases were washed once with water, dried over sodium sulfate and evaporated down.

1. customAfter separation of the phases
2. extractionthe aqueous phase was extracted once with dichloromethane
3. washthe combined organic phases were washed once with water
4. dry with materialdried over sodium sulfate
5. customevaporated down