反应详情

To a solution of the above ester (0.6 g, 0.0015 mol) in ethanol (5 ml) 4 N sodium hydroxide (0.8 ml) was added and the mixture was stirred at room temperature for 2.5 h and then left in a freezer overnight. The cold reaction mixture was allowed to warm to room temperature during 1 h, and 4 N hydrochloric acid (1.2 ml) and water (10 ml) were added. The mixture was extracted with dichloromethane (2×100 ml). The combined organic extracts were dried (MgSO4) and the solvent was evaporated in vacuo. The residue was reevaporated with a mixture of acetone and isopropyl acetate and then treated with a mixture of acetone and isopropyl acetate to give a solid which was isolated and dried in vacuo. This afforded 0.33 g of the title compound.

1. waitleft in a freezer overnight
2. customThe cold reaction mixture
3. temperatureto warm to room temperature during 1 h
4. extractionThe mixture was extracted with dichloromethane (2×100 ml)
5. dry with materialThe combined organic extracts were dried (MgSO4)
6. customthe solvent was evaporated in vacuo
7. customThe residue was reevaporated with a mixture of acetone and isopropyl acetate
8. additiontreated with a mixture of acetone and isopropyl acetate
9. customto give a solid which
10. customwas isolated
11. customdried in vacuo