反应详情

A suspension of 4-(4′-bromo-2′-fluoro-biphenyl-4-yl)-4-oxo-butyric acid, methyl ester (2.94 g, 0.00805 mol) in 6 M hydrochloric acid was refluxed for 23 hours and allowed to cool. The solids were filtered, washed with 0.1 M hydrochloric acid, and dried under house vacuum to give 2.76 g of 4-(4′-bromo-2′-fluoro-biphenyl-4-yl)-4-oxo-butyric acid as a pale yellow solid; mp 145-147° C.

1. temperaturewas refluxed for 23 hours
2. temperatureto cool
3. filtrationThe solids were filtered
4. washwashed with 0.1 M hydrochloric acid
5. customdried under house vacuum