HCID 86583515, compound → HCID 18364125, compound

HRID 1979143Notes

Reaction equation

HRID 1979143 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14](=[O:21])[CH2:15][CH2:16][C:17]([O:19]C)=[O:18])=[CH:10][CH:9]=2)=[C:4]([F:22])[CH:3]=1>Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]([C:14](=[O:21])[CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:12][CH:13]=2)=[C:4]([F:22])[CH:3]=1

Participants

3

Reactant 1

HCID 86583515HCID 86583515, compound

Product 1

HCID 18364125HCID 18364125, compoundYield 97.6%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A suspension of 4-(4′-bromo-2′-fluoro-biphenyl-4-yl)-4-oxo-butyric acid, methyl ester (2.94 g, 0.00805 mol) in 6 M hydrochloric acid was refluxed for 23 hours and allowed to cool. The solids were filtered, washed with 0.1 M hydrochloric acid, and dried under house vacuum to give 2.76 g of 4-(4′-bromo-2′-fluoro-biphenyl-4-yl)-4-oxo-butyric acid as a pale yellow solid; mp 145-147° C.

Workup

  1. temperaturewas refluxed for 23 hours
  2. temperatureto cool
  3. filtrationThe solids were filtered
  4. washwashed with 0.1 M hydrochloric acid
  5. customdried under house vacuum

Sources & evidence

ORD record
ord-0c9ac90402bd4eda825e35399af44c3e
Source dataset
uspto-grants-2001_05
Patent number
US06239288B1

Reaction notes

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