Hydroxyamine hydrochloride → HCID 73432314, compound

HRID 1979144Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14](=O)[CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:10][CH:9]=2)=[C:4]([F:21])[CH:3]=1.Cl.[NH2:23][OH:24]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14](=[N:23][OH:24])[CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:10][CH:9]=2)=[C:4]([F:21])[CH:3]=1

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 18364125HCID 18364125, compound

Product 1

HCID 73432314HCID 73432314, compoundYield 91%

Procedure

In a manner similar to that described for Example 4, Step (c), 4-(4′-bromo-2′-fluoro-biphenyl-4-yl)-4-oxo-butyric acid (1.05 g, 0.00300 mol) was allowed to react with hydroxylamine hydrochloride (0.256 g, 0.00368 mol) to give 1.00 g of 4-(4′-bromo-2′-fluoro-biphenyl-4-yl)-4-hydroxyimino-butyric acid as a white solid; mp 163-164° C.

Sources & evidence

ORD record: ord-d7abb4bfb51e4226a7f983be3fad67f3
Source dataset: uspto-grants-2001_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06239288B1

Reaction notes

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