反应详情

In a manner similar to Example 4, Step (b), 4-(3′-fluoro-biphenyl-4-yl)-4-oxo-butyric acid, methyl ester (1.0968 g, 0.00383 mol) was refluxed in 6 M aqueous hydrochloric acid (20 mL) to give 1.007 g of 4-(3′-fluoro-biphenyl-4-yl)-4-oxo-butyric acid as a pale orange solid; mp 153-155° C.