HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 4-(3'-Fluoro-biphenyl-4-yl)-4-hydroxyimino-butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | 4-(3'-Fluoro-biphenyl-4-yl)-4-oxo-butyric acid | HCID 23005236 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(3'-Fluoro-biphenyl-4-yl)-4-hydroxyimino-butyric acid | HCID 73432320 | — |
Reaction Steps
In a manner similar to Example 4, Step (c), 4-(3′-fluoro-biphenyl-4-yl)-4-oxo-butyric acid (0.9258 g, 0.00340 mol) was allowed to react with hydroxylamine hydrochloride (0.284 g, 0.00409 mol) in the presence of sodium carbonate (0.434 g, 0.00409 mol) in absolute ethanol (19 mL) to give 4-(3′-fluoro-biphenyl-4-yl)-4-hydroxyimino-butyric acid as a pale gray solid; mp 155-157° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06239288B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-3b512b01193a4e939b184a4d8ad89889 |
| Source note | uspto-grants-2001_05 |