Sodium Carbonate → 4-(3'-Fluoro-biphenyl-4-yl)-4-hydroxyimino-butyric acid

HRID 1979166Notes

Reaction equation

HRID 1979166 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([C:14](=O)[CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.Cl.[NH2:22][OH:23].C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([C:14](=[N:22][OH:23])[CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 230052364-(3'-Fluoro-biphenyl-4-yl)-4-oxo-butyric acid

Product 1

HCID 734323204-(3'-Fluoro-biphenyl-4-yl)-4-hydroxyimino-butyric acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a manner similar to Example 4, Step (c), 4-(3′-fluoro-biphenyl-4-yl)-4-oxo-butyric acid (0.9258 g, 0.00340 mol) was allowed to react with hydroxylamine hydrochloride (0.284 g, 0.00409 mol) in the presence of sodium carbonate (0.434 g, 0.00409 mol) in absolute ethanol (19 mL) to give 4-(3′-fluoro-biphenyl-4-yl)-4-hydroxyimino-butyric acid as a pale gray solid; mp 155-157° C.

Sources & evidence

ORD record
ord-3b512b01193a4e939b184a4d8ad89889
Source dataset
uspto-grants-2001_05
Patent number
US06239288B1

Reaction notes

Loading…