反应详情

In a manner similar to Example 17, Step (b), 4-(4′-tert-butyl-biphenyl-4-yl)-4-oxo-butyric acid, methyl ester (0.43 g, 0.0013 mol) was allowed to react with 1.0 M aqueous sodium hydroxide (2.0 mL, 0.002 mol) in THF-methanol (5 mL each) to give 0.308 g of 4-(4′-tert-butyl-biphenyl-4-yl)-4-oxo-butyric acid as a white solid; mp 172.0-173.5° C.