HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 4-(4'-Tert-butyl-biphenyl-4-yl)-4-oxo-butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-(4'-Tert-butyl-biphenyl-4-yl)-4-oxo-butyric acid, methyl ester | HCID 70212258 | — |
| Solvent | MeOH tetrahydrofuran | HCID 21899815 | — |
| Product | 4-(4'-Tert-butyl-biphenyl-4-yl)-4-oxo-butyric acid | HCID 18364135 | 76.3% |
Reaction Steps
In a manner similar to Example 17, Step (b), 4-(4′-tert-butyl-biphenyl-4-yl)-4-oxo-butyric acid, methyl ester (0.43 g, 0.0013 mol) was allowed to react with 1.0 M aqueous sodium hydroxide (2.0 mL, 0.002 mol) in THF-methanol (5 mL each) to give 0.308 g of 4-(4′-tert-butyl-biphenyl-4-yl)-4-oxo-butyric acid as a white solid; mp 172.0-173.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06239288B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-efa438a7ac8a45d0b31baa7e74f8bd80 |
| Source note | uspto-grants-2001_05 |