Hydrochloric Acid → HCID 86756943, compound

Participants

Reaction Steps

A solution of 0.300 g of (E)-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-isobutyl-4-methyl-2′-[2-(4-piperidinyl)acetyl]valerohydrazide in 3 ml of 4M hydrogen chloride in dioxan was stirred for 2.5 hours at room temperature and diluted with diethyl ether. The solid was filtered off, washed with diethyl ether and dried to give 0.256 g of (E)-2(R)-[1(S)-(hydroxycarbamoyl)-4-phenyl-3-butenyl]-2′-isobutyl-4-methyl-2′-[2-(4-piperidinyl)acetyl]valerohydrazide hydrochloride in the form of an off-white solid.

Provenance & Evidence