Hydrochloric Acid → HCID 86756943, compound

HRID 1979236Notes

Reaction equation

HRID 1979236 reaction equation
O1CCCCC1[O:7][NH:8][C:9]([C@H:11]([C@@H:21]([CH2:39][CH:40]([CH3:42])[CH3:41])[C:22]([NH:24][N:25]([CH2:35][CH:36]([CH3:38])[CH3:37])[C:26](=[O:34])[CH2:27][CH:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1)=[O:23])[CH2:12]/[CH:13]=[CH:14]/[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:10].[ClH:43]>O1CCOCC1.C(OCC)C>[ClH:43].[OH:7][NH:8][C:9]([C@H:11]([C@@H:21]([CH2:39][CH:40]([CH3:42])[CH3:41])[C:22]([NH:24][N:25]([CH2:35][CH:36]([CH3:37])[CH3:38])[C:26](=[O:34])[CH2:27][CH:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1)=[O:23])[CH2:12]/[CH:13]=[CH:14]/[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:10]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86756945HCID 86756945, compound

Product 1

HCID 86756943HCID 86756943, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of 0.300 g of (E)-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-isobutyl-4-methyl-2′-[2-(4-piperidinyl)acetyl]valerohydrazide in 3 ml of 4M hydrogen chloride in dioxan was stirred for 2.5 hours at room temperature and diluted with diethyl ether. The solid was filtered off, washed with diethyl ether and dried to give 0.256 g of (E)-2(R)-[1(S)-(hydroxycarbamoyl)-4-phenyl-3-butenyl]-2′-isobutyl-4-methyl-2′-[2-(4-piperidinyl)acetyl]valerohydrazide hydrochloride in the form of an off-white solid.

Workup

  1. filtrationThe solid was filtered off
  2. washwashed with diethyl ether
  3. customdried

Sources & evidence

ORD record
ord-f0ea19bd791341699f1863c65952c9e2
Source dataset
uspto-grants-2001_05
Patent number
US06239151B1

Reaction notes

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