Trifluoroacetic acid → HCID 69953237, compound

HRID 1979267Notes

Reaction equation

HRID 1979267 reaction equation
[C:1]([NH:9][CH2:10][CH2:11][C@@H:12]([C@@H:20]([CH2:37][CH:38]([CH3:40])[CH3:39])[C:21]([NH:23][N:24]([C:29](=[O:36])[CH2:30][N:31]1[CH:35]=[CH:34][N:33]=[CH:32]1)[CH2:25][CH:26]([CH3:28])[CH3:27])=[O:22])[C:13]([O:15]C(C)(C)C)=[O:14])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>ClCCl>[C:1]([NH:9][CH2:10][CH2:11][C@@H:12]([C@@H:20]([CH2:37][CH:38]([CH3:40])[CH3:39])[C:21]([NH:23][N:24]([C:29](=[O:36])[CH2:30][N:31]1[CH:35]=[CH:34][N:33]=[CH:32]1)[CH2:25][CH:26]([CH3:28])[CH3:27])=[O:22])[C:13]([OH:15])=[O:14])(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69952840HCID 69952840, compound

Product 1

HCID 69953237HCID 69953237, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 0.907 g of 2(R)-[3-benzamido-1(S)-(tert-butoxycarbonyl)propyl]-2′-[2-(1H-imidazol-1-yl)acetyl]-2′-isobutyl-4-methylvalerohydrazide in 8 ml of dichloromethane was treated with 6 ml of trifluoroacetic acid. The mixture was stirred at room temperature for 2 hours and then the solvent was evaporated. The residue was dried in vacuo to give 2(R)-[3-benzamido-1(S)-(carboxy)propyl]-2′-[2-(1H-imidazol-1-yl)acetyl]-2′-isobutyl-4-methylvalerohydrazide in the form of a pale orange oil.

Workup

  1. customthe solvent was evaporated
  2. customThe residue was dried in vacuo

Sources & evidence

ORD record
ord-c18f3fc7c6244e08b3972c4e7ab19901
Source dataset
uspto-grants-2001_05
Patent number
US06239151B1

Reaction notes

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