Pyridine → HCID 69663720, compound

HRID 1979285Notes

Reaction equation

HRID 1979285 reaction equation
[N:1]1C=CC=[CH:3][CH:2]=1.[C:7]([O:10][C:11](=[O:13])C)(=[O:9])[CH3:8]>C(Cl)Cl>[C:2]([NH2:1])(=[O:9])[CH3:3].[O:10]1[CH2:7][CH2:8][NH:1][C:11]1=[O:13]

Participants

4

Reactant 2

HCID 1049PyridineHCID 7918Acetic Anhydride

Product 1

HCID 69663720HCID 69663720, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To the crude oxazolidinone amine residue 16a in DCM at room temperature was added pyridine (30 equivalents) and acetic anhydride (20 equivalents). The solution was stirred for 2 hrs and concentrated in vacuo. The oxazolidinone acetamide residue was purified by HPLC to provide pure oxazolidinone acetamide.

Workup

  1. concentrationconcentrated in vacuo
  2. customThe oxazolidinone acetamide residue was purified by HPLC

Sources & evidence

ORD record
ord-8d929a4cd8884d8e975fec773dc30976
Source dataset
uspto-grants-2001_05
Patent number
US06239152B1

Reaction notes

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