Ethane, 2-bromo-1,1-diethoxy- → HCID 21201533, compound

HRID 1979316Notes

Reaction equation

HRID 1979316 reaction equation
[O:1]=[C:2]1[NH:8][C:7]2[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=2[N:5]([C:13](=[O:18])[C:14]([CH3:17])([CH3:16])[CH3:15])[CH2:4][CH:3]1[NH:19][C:20]([O:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[O:21].[CH2:30]([O:32][CH:33]([O:36][CH2:37][CH3:38])[CH2:34]Br)[CH3:31]>>[CH2:30]([O:32][CH:33]([O:36][CH2:37][CH3:38])[CH2:34][N:8]1[C:7]2[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=2[N:5]([C:13](=[O:18])[C:14]([CH3:17])([CH3:15])[CH3:16])[CH2:4][CH:3]([NH:19][C:20]([O:22][CH2:23][C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)=[O:21])[C:2]1=[O:1])[CH3:31]

Participants

3

Reactant 2

HCID 74852Ethane, 2-bromo-1,1-diethoxy-HCID 21201933HCID 21201933, compound

Product 1

HCID 21201533HCID 21201533, compound

Procedure

Step 2 of Example 1 was repeated except that 2-oxo-3-benzyloxycarbonylamino-5-pivaloyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine was used instead of 2-oxo-3-tert-butoxycarbonylamino-5-pivaloyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine, and that bromoacetaldehyde diethylacetal was used instead of 2-bromo-2′-methylacetophenone, to thereby obtain the title compound.

Sources & evidence

ORD record
ord-cebc34147cbe4bb3aa3e67e93ef0f779
Source dataset
uspto-grants-2001_05
Patent number
US06239131B1

Reaction notes

Loading…