HCID 21201561, compound → HCID 21201962, compound

HRID 1979327Notes

Reaction equation

HRID 1979327 reaction equation
[N+:1]([C:4]1[CH:45]=[CH:44][CH:43]=[CH:42][C:5]=1[C:6](=[O:41])[CH2:7][N:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]([C:19](=[O:24])[C:20]([CH3:23])([CH3:22])[CH3:21])[CH2:11][CH:10]([NH:25][C:26]([NH:28][C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([C:35]([O:37][CH2:38][CH3:39])=[O:36])[CH:30]=2)=[O:27])[C:9]1=[O:40])([O-])=O>[C].[Pd].CCO>[NH2:1][C:4]1[CH:45]=[CH:44][CH:43]=[CH:42][C:5]=1[C:6](=[O:41])[CH2:7][N:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]([C:19](=[O:24])[C:20]([CH3:23])([CH3:21])[CH3:22])[CH2:11][CH:10]([NH:25][C:26]([NH:28][C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([C:35]([O:37][CH2:38][CH3:39])=[O:36])[CH:30]=2)=[O:27])[C:9]1=[O:40]

Participants

4

Reactant 1

HCID 21201561HCID 21201561, compound

Product 1

HCID 21201962HCID 21201962, compoundYield 42%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

Etanol (20 ml) and 10% palladium carbon (70 mg) were added to 1-[1-(2-nitrophenacyl)-2-oxo-5-pivaloyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl]-3-(3-ethoxycarbonylphenyl)urea (700 mg), the mixture was stirred at room temperature under hydrogen atmosphere for 3 hours. The reaction mixture was filtrated and the filtrate was concentrated under reduced pressure, to thereby to obtain 280 mg of the title compound as colorless oil.

Workup

  1. filtrationThe reaction mixture was filtrated
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-3e249f0d028d4b57a27174e6256da5a3
Source dataset
uspto-grants-2001_05
Patent number
US06239131B1

Reaction notes

Loading…