HCID 21201678, compound → HCID 21201619, compound

HRID 1979338Notes

Reaction equation

HRID 1979338 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]([CH2:18][CH2:19][C:20]#[N:21])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[F:17])([O-])=O>CO.[C].[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]([CH2:18][CH2:19][C:20]#[N:21])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[F:17]

Participants

4

Reactant 1

HCID 21201678HCID 21201678, compound

Product 1

HCID 21201619HCID 21201619, compoundYield 108.2%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

N-(2-Nitrophenyl)-N-(2-cyanoethyl)-2-fluoroaniline (6.37 g) was dissolved in methanol (60 ml), 10% palladium carbon (0.60 g) was added, the mixture was stirred for 3 hours under hydrogen atmosphere. Palladium carbon was removed by filtration, the filtrate was concentrated under reduced pressure, to thereby obtain 6.17 g of the titled compound (Yield: 100%).

Workup

  1. customPalladium carbon was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-35aff1df07194c92b56bd35db691e940
Source dataset
uspto-grants-2001_05
Patent number
US06239131B1

Reaction notes

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