反应详情

2-Oxo-3-tert-butoxycarbonylamino-5-(2-cyclohexen-1-yl)-8-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine (500 mg) was suspended in xylene (20 ml), nitrobenzene (831 mg) and 10% palladium carbon (250 mg) were added therto, and the mixture was refluxed for 2 hours. The reaction mixture was allowed to cool, filtrated, and the filtrate was concentrated under reduced pressure. Diisopropyl ether was added to the residue, crystals so precipitated were collected by filtration, to thereby obtain 413 mg of the titled compound (Yield: 83%).

1. temperaturewas refluxed for 2 hours
2. temperatureto cool
3. filtrationfiltrated
4. concentrationthe filtrate was concentrated under reduced pressure
5. additionDiisopropyl ether was added to the residue, crystals
6. customso precipitated
7. filtrationwere collected by filtration