Trifluoroacetic acid → HCID 69693023, compound

HRID 1979492Notes

Reaction equation

HRID 1979492 reaction equation
[C:1]([C:5]([CH2:7][N:8]1[C:14]2[CH:15]=[C:16]([CH3:19])[CH:17]=[CH:18][C:13]=2[N:12]([CH:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[CH2:11][C@@H:10]([NH:26][C:27]([NH:29][C:30]2[CH:35]=[CH:34][C:33](C(OC(C)(C)C)=O)=[CH:32][CH:31]=2)=[O:28])[C:9]1=[O:43])=[O:6])([CH3:4])([CH3:3])[CH3:2].FC(F)(F)[C:46]([OH:48])=[O:47]>C(Cl)Cl>[C:1]([C:5]([CH2:7][N:8]1[C:14]2[CH:15]=[C:16]([CH3:19])[CH:17]=[CH:18][C:13]=2[N:12]([CH:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[CH2:11][C@@H:10]([NH:26][C:27](=[O:28])[NH:29][C:30]2[CH:31]=[C:32]([CH:33]=[CH:34][CH:35]=2)[C:46]([OH:48])=[O:47])[C:9]1=[O:43])=[O:6])([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 54420953HCID 54420953, compound

Product 1

HCID 69693023HCID 69693023, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(R)-(−)-1-(1-tert-butylcarbonylmethyl-2-oxo-5-cyclohexyl-8-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl)-3-(4-tert-butoxycarbonylphenyl)urea (100 mg) was dissolved in methylene chloride (1 ml), trifluoroacetic acid (1 ml) was added, the mixture was stirred at room temperature for 30 minutes. After the solvent was evaporated, isopropyl ether was added to the residue, powder so precipitated was collected by filtration, to thereby obtain 50 mg of the title compound.

Workup

  1. customAfter the solvent was evaporated
  2. additionisopropyl ether was added to the residue, powder
  3. customso precipitated
  4. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-314d5410c92a4808b6c0d910851b7d25
Source dataset
uspto-grants-2001_05
Patent number
US06239131B1

Reaction notes

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