1-Octanol → HCID 86739747, compound

HRID 1979526Notes

Reaction equation

HRID 1979526 reaction equation
[NH2:1][C:2]1[C:7](C(OC)=O)=[N:6][CH:5]=[CH:4][N:3]=1.[CH3:12][O-:13].[Na+].[CH2:15]([OH:23])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]>>[NH2:1][C:2]1([C:12]([O:23][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[O:13])[CH:7]=[N:6][CH:5]=[CH:4][NH:3]1

Participants

4

Reactant 3

HCID 9571-OctanolHCID 72669Methyl 3-aminopyrazinecarboxylateHCID 10942334Sodium Methoxide

Product 1

HCID 86739747HCID 86739747, compound

Procedure

Together there was stirred methyl (2-aminopyrazin-3-yl)formate (5 g; 0.327 mol) and n-octanol (30 ml), together with sodium methoxide (0.3 g), at 85° C. for 1 hour, then 160° C. for 2 days. The n-octanol was distilled off under vacuum, and the residue was passed through a silica gel column, eluting with dichloromethane, to give the title compound (5.78 g).

Workup

  1. distillationThe n-octanol was distilled off under vacuum
  2. washeluting with dichloromethane

Sources & evidence

ORD record
ord-69eb8c6b75154786b590b43e237f47ed
Source dataset
uspto-grants-1984_11
Patent number
US04481202

Reaction notes

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