Ammonia → 6-Chloro-3-nitropyridin-2-ylamine

Participants

Reaction Steps

There were led into a solution of 21.3kg of 2,6-dichloro-3-nitropyridine (90%, water wet) in 100 liters of isopropanol with stirring at 20°-30° C. 6.8 kg (400 moles) of ammonia gas (there can also be dropped in liquid ammonia). Then stirring was carried out for 24 hours at room temperature. The 2-amino-3-nitro-6-chloro-pyridine formed was further reacted in suspension after the testing for unreacted 2,6-dichloro-3-nitro-pyridine by means of thin layer chromatography or gas chromatography is negative.

Provenance & Evidence