Ammonia → 6-Chloro-3-nitropyridin-2-ylamine

HRID 1979528Notes

Reaction equation

HRID 1979528 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([Cl:11])[N:3]=1.[NH3:12]>C(O)(C)C>[NH2:12][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([Cl:11])[N:3]=1

Participants

4

Reactant 2

HCID 222Ammonia2×HCID 852392,6-Dichloro-3-nitropyridine

Product 1

HCID 27240356-Chloro-3-nitropyridin-2-ylamine

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

There were led into a solution of 21.3kg of 2,6-dichloro-3-nitropyridine (90%, water wet) in 100 liters of isopropanol with stirring at 20°-30° C. 6.8 kg (400 moles) of ammonia gas (there can also be dropped in liquid ammonia). Then stirring was carried out for 24 hours at room temperature. The 2-amino-3-nitro-6-chloro-pyridine formed was further reacted in suspension after the testing for unreacted 2,6-dichloro-3-nitro-pyridine by means of thin layer chromatography or gas chromatography is negative.

Workup

  1. stirringThen stirring

Sources & evidence

ORD record
ord-c1b38820b11142f49ac61afcb2a6317a
Source dataset
uspto-grants-1984_11
Patent number
US04481205

Reaction notes

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