Potassium Hydroxide → HCID 136399295, compound

Participants

Reaction Steps

A solution of hydroxylamine hydrochloride (0.13 g) in ethanol (10 ml) was treated with potassium hydroxide (0.11 g). A solution of 4-methyl-5-[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]amino]-4H-1,2,4-triazole-3-carboxaldehyde (0.54 g) in ethanol (10 ml) was added. The mixture was stirred at room temperature for 15 min and then filtered. The filtrate was evaporated and the residue was crystallised from a mixture of ethanol (5 ml) and ethyl acetate (5 ml) to give the title compound as a white crystalline solid (0.21 g) m.p. 187°-188°.

Provenance & Evidence