Potassium Hydroxide → HCID 136399295, compound

HRID 1979537Notes

Reaction equation

HRID 1979537 reaction equation
Cl.[NH2:2][OH:3].[OH-].[K+].[CH3:6][N:7]1[C:11]([NH:12][CH2:13][CH2:14][CH2:15][O:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([CH2:23][N:24]3[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]3)[CH:18]=2)=[N:10][N:9]=[C:8]1[CH:30]=O>C(O)C>[CH3:6][N:7]1[C:11]([NH:12][CH2:13][CH2:14][CH2:15][O:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([CH2:23][N:24]3[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]3)[CH:18]=2)=[N:10][N:9]=[C:8]1[CH:30]=[N:2][OH:3]

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 20439407HCID 20439407, compound

Product 1

HCID 136399295HCID 136399295, compoundYield 37.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A solution of hydroxylamine hydrochloride (0.13 g) in ethanol (10 ml) was treated with potassium hydroxide (0.11 g). A solution of 4-methyl-5-[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]amino]-4H-1,2,4-triazole-3-carboxaldehyde (0.54 g) in ethanol (10 ml) was added. The mixture was stirred at room temperature for 15 min and then filtered. The filtrate was evaporated and the residue was crystallised from a mixture of ethanol (5 ml) and ethyl acetate (5 ml) to give the title compound as a white crystalline solid (0.21 g) m.p. 187°-188°.

Workup

  1. filtrationfiltered
  2. customThe filtrate was evaporated
  3. customthe residue was crystallised from a mixture of ethanol (5 ml) and ethyl acetate (5 ml)

Sources & evidence

ORD record
ord-2f3cbd32fc8d48289f273d17ab91b599
Source dataset
uspto-grants-1984_11
Patent number
US04481199

Reaction notes

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