Hydrochloric Acid → HCID 10105638, compound

HRID 1979543Notes

Reaction equation

HRID 1979543 reaction equation
[CH3:1][CH:2]([CH2:6][CH2:7]/[CH:8]=[C:9](\[CH3:16])/[CH2:10][CH2:11][CH:12]=[C:13]([CH3:15])[CH3:14])[CH2:3][C:4]#N.[OH-:17].[K+].C(O)C([OH:22])C.Cl>O>[CH3:1][CH:2]([CH2:6][CH2:7]/[CH:8]=[C:9](\[CH3:16])/[CH2:10][CH2:11][CH:12]=[C:13]([CH3:15])[CH3:14])[CH2:3][C:4]([OH:22])=[O:17]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 1030Propylene GlycolHCID 14797Potassium HydroxideHCID 20220949HCID 20220949, compound

Product 1

HCID 10105638HCID 10105638, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 40 g. of the product obtained in the above (b) step, there were added 35 g. of potassium hydroxide, 15 ml. of water and 80 ml. of propylene glycol, and the mixture was stirred at 130° C. for 7 hours. The reaction mixture was then made acidic by addition of hydrochloric acid, and was then extracted with n-hexane. The extract was washed with water and dried, and the solvent was removed by evaporation. The residue was purified by silica gel column chromatography to obtain 36 g. of the desired oily product.

Workup

  1. additionwere added 35 g
  2. extractionwas then extracted with n-hexane
  3. washThe extract was washed with water
  4. customdried
  5. customthe solvent was removed by evaporation
  6. customThe residue was purified by silica gel column chromatography
  7. customto obtain 36 g

Sources & evidence

ORD record
ord-a3d8a90f5d0643a5b86f4944baf02bc5
Source dataset
uspto-grants-1984_11
Patent number
US04481217

Reaction notes

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