反应详情

温度

10 °C

To 150 ml. of anhydrous diethyl ether there was added 1.9 g. of lithium aluminum hydride. To the mixture was dropwise added, under stirring and at 10° C., 1.53 g. of the carboxylic acid compound obtained in Example 1. The resulting mixture was then stirred at room temperature for 1 hour, and 1 ml. of ethyl acetate and 1 ml. of water were then added thereto. The mixture was subsequently washed with water and dried. The solvent was removed by evaporation and the resulting residual oil was purified by silica gel column chromatography to obtain 13.8 g. of the desired oily product.

1. additionTo the mixture was dropwise added
2. stirringThe resulting mixture was then stirred at room temperature for 1 hour
3. washThe mixture was subsequently washed with water
4. customdried
5. customThe solvent was removed by evaporation
6. customthe resulting residual oil was purified by silica gel column chromatography
7. customto obtain 13.8 g