Dimethylamine → HCID 13225518, compound

HRID 1979573Notes

Reaction equation

HRID 1979573 reaction equation
Cl[C:2]1[N:3]=[CH:4][C:5]2[CH2:6][N:7]=[C:8]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[F:24])[C:9]3[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:10]=3[C:11]=2[N:12]=1.[CH3:25][NH:26][CH3:27]>CN(C)C=O>[Cl:17][C:15]1[CH:14]=[CH:13][C:10]2[C:11]3[N:12]=[C:2]([N:26]([CH3:27])[CH3:25])[N:3]=[CH:4][C:5]=3[CH2:6][N:7]=[C:8]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[F:24])[C:9]=2[CH:16]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 13225515HCID 13225515, compound

Product 1

HCID 13225518HCID 13225518, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 4.0 g (0.0112 mol) of 2,9-dichloro-7-(2-fluorophenyl)-5H-pyrimido[5,4-d][2]benzazepine in 15 ml of N,N-dimethylformamide was cooled in an ice bath and saturated with dimethylamine. After 18 hr at room temperature, 80 ml of ice water was added and the precipitate was collected by filtration and recrystallized twice from methanol to give the end product as white rods, mp 175°-179°.

Workup

  1. filtrationthe precipitate was collected by filtration
  2. customrecrystallized twice from methanol
  3. customto give the end product as white rods, mp 175°-179°

Sources & evidence

ORD record
ord-9f16d6d1f7ba4ccebc945522ce4f2398
Source dataset
uspto-grants-1984_11
Patent number
US04481142

Reaction notes

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