反应详情

Acetyl chloride (0.51 g, 6.5 mmole) was added dropwise to a stirred solution of 2-hydrazino-5-nitropyridine (1.0 g, 6.5 mmole) in tetrahydrofuran (20 ml). Pyridine (0.51 g, 6.5 mmole) was added, the mixture stirred for 0.5 h, and then poured into water (200 ml). The aqueous solution was extracted with ethyl actate, the extract dried (MgSO4) and the solvent removed under reduced pressure. Recrystallisation of the residue from 1,2-dichloroethane afforded the pure product, 1.1 g, 86%, as a cream coloured solid, m.p. 226°-227° C.

1. extractionThe aqueous solution was extracted with ethyl actate
2. dry with materialthe extract dried (MgSO4)
3. customthe solvent removed under reduced pressure
4. customRecrystallisation of the residue from 1,2-dichloroethane
5. customafforded the pure product, 1.1 g, 86%