反应详情

温度

100 °C

Following a procedure of P. Brookes, et al., J. Chem. Soc., 3165 (1957), 1-benzyl-4-piperidinone (44.6 g, 0.234 mol) and hydroxylamine hydrochloride (14.0 g, 0.201 mol) are added to 140 ml of dry pyridine and the resulting mixture is heated to 100° C. in an oil bath for 3 hours. The resulting solid is cooled overnight, filtered and crystallized from 1 liter of ethanol. The product is collected as colorless needles, 38.17 g, in two groups with melting point of 225°-237° C., decomposed depending upon the rate of heating.

1. temperatureThe resulting solid is cooled overnight
2. filtrationfiltered
3. customcrystallized from 1 liter of ethanol
4. customThe product is collected as colorless needles, 38.17 g, in two groups with melting point of 225°-237° C.
5. temperatureof heating