Hydroxyamine hydrochloride → HCID 86739757, compound

HRID 1979692Notes

Reaction equation

HRID 1979692 reaction equation
O=[C:2]([C:8]1[S:9][C:10]2[CH2:16][CH2:15][CH2:14][CH2:13][C:11]=2[CH:12]=1)[C:3]([O:5][CH2:6][CH3:7])=[O:4].C([O-])(=O)C.[Na+].Cl.[NH2:23][OH:24]>C(O)C>[OH:24][N:23]=[C:2]([C:8]1[S:9][C:10]2[CH2:16][CH2:15][CH2:14][CH2:13][C:11]=2[CH:12]=1)[C:3]([O:5][CH2:6][CH3:7])=[O:4]

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 24971908HCID 24971908, compound

Product 1

HCID 86739757HCID 86739757, compoundYield 98.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 14.0 g of ethyl α-oxo-α-(4,5,6,7-tetrahydro-2-benzothienyl)acetate in 300 ml of ethanol containing 5.31 g of sodium acetate and 6.50 g of hydroxylamine hydrochloride was heated at reflux for three hours. The reaction mixture was cooled and the solvent was removed by evaporation under reduced pressure to provide 14.7 g of ethyl α-hydroxyimino-α-(4,5,6,7-tetrahydro-2-benzothienyl)acetate.

Workup

  1. temperatureat reflux for three hours
  2. temperatureThe reaction mixture was cooled
  3. customthe solvent was removed by evaporation under reduced pressure

Sources & evidence

ORD record
ord-8e7f10541eb741958fc36342788cc40f
Source dataset
uspto-grants-1984_11
Patent number
US04482553

Reaction notes

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