Hydrochloric Acid → HCID 20438530, compound

HRID 1979704Notes

Reaction equation

HRID 1979704 reaction equation
[O:1]=[C:2]1[N:7]2[CH2:8][CH2:9][CH2:10][C:6]2=[N:5][CH:4]=[C:3]1[C:11]([O:13]CC)=[O:12].Cl>[OH-].[Na+]>[O:1]=[C:2]1[N:7]2[CH2:8][CH2:9][CH2:10][C:6]2=[N:5][CH:4]=[C:3]1[C:11]([OH:13])=[O:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 12778914HCID 12778914, compound

Product 1

HCID 20438530HCID 20438530, compoundYield 66.7%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

10.4 g of ethyl 4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-3-carboxylate are dissolved in 50 ml of a 5% by W/V sodium hydroxide solution and after two hours the pH of the reaction mixture is adjusted to 2.5 with 36% by W/V hydrochloric acid solution. The precipitated crystals are filtered and washed with a small amount of cold water. 6.0 g (66.7%) of 4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-3-carboxylic acid are obtained, melting at 146° to 148° C. (decomposition).

Workup

  1. filtrationThe precipitated crystals are filtered
  2. washwashed with a small amount of cold water

Sources & evidence

ORD record
ord-efd169ac7b9d4279852bb2aad5e13680
Source dataset
uspto-grants-1984_11
Patent number
US04482557

Reaction notes

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