Chloroacetyl chloride → 86518-41-4

HRID 1979727Notes

Reaction equation

HRID 1979727 reaction equation
[Cl:1][CH2:2][C:3](Cl)=[O:4].[CH3:6][N:7]1[CH2:12][CH2:11][CH2:10][CH:9]([OH:13])[CH2:8]1>CN(C)C=O>[ClH:1].[Cl:1][CH2:2][C:3]([O:13][CH:9]1[CH2:10][CH2:11][CH2:12][N:7]([CH3:6])[CH2:8]1)=[O:4]

Participants

4

Reactant 2

HCID 6577Chloroacetyl chlorideHCID 980163-Piperidinol, 1-methyl-

Product 1

HCID 2043887886518-41-4Yield 108.7%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

11.3 g of Chloroacetylchloride were added to a solution of 11.4 g of N-methyl-3-piperidinol in 20 ml of dimethylformamide, at 20° to 25° C. The reaction product, which formed immediately, was allowed to stand at this temperature for 24 hours. It was then collected by filtration and recrystallized from isopropanol to provide 12.4 g of N-methyl-3-piperidyl chloroacetate hydrochloride. (II, R=CH3, R1 =R2 =R3 =H, X=Cl), m.p. 168° C.

Workup

  1. customThe reaction product, which formed immediately
  2. filtrationIt was then collected by filtration
  3. customrecrystallized from isopropanol

Sources & evidence

ORD record
ord-9f4c3be4a40c45b1b423b8a5e2cdff9e
Source dataset
uspto-grants-1984_11
Patent number
US04482561

Reaction notes

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