反应详情

温度

70 °C

2 g of sodium 3-acetoxymethyl-7-phenoxyacetamido-3-cephem-4-carboxylate were dissolved in 20 ml of 50% v/v aqueous methanol, and 20 g of calcium bromide dihydrate were added to the resulting solution. The mixture was then stirred at 70° C. for 50 minutes, after which it was treated as described in Example 2, to give 1.55 g of 3-methoxymethyl-7-phenoxyacetamido-3-cephem-4-carboxylic acid, in the form of a yellow solid.

1. additionwere added to the resulting solution
2. additionafter which it was treated