Benzene → HCID 12962355, compound

HRID 1979880Notes

Reaction equation

HRID 1979880 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[NH:12][CH2:11][CH2:10][S:9]2)[CH:5]=[CH:6][CH:7]=1.C1C=CC=CC=1.[Cl:19][CH:20]([Cl:24])[C:21](Cl)=[O:22]>C(N(CC)CC)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[N:12]([C:21](=[O:22])[CH:20]([Cl:24])[Cl:19])[CH2:11][CH2:10][S:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 241BenzeneHCID 6593Dichloroacetyl chlorideHCID 108528THIAZOLIDINE, 2-(M-CHLOROPHENYL)

Product 1

HCID 12962355HCID 12962355, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Five (5) grams of 2-m-chlorophenyl thiazolidine was dissolved in 50 ml. of benzene and 2.6 g. of triethylamine and the mixture was stirred in a room temperature water bath, while 3.7 g. of dichloroacetyl chloride was added dropwise. After standing for about 30 minutes, the mixture was washed with water, separated and dried over magnesium sulfate and the benzene stripped under vacuum. There was obtained a yield of 7.2 g. of an oil, the title compound, ND30 =1.5805.

Workup

  1. washthe mixture was washed with water
  2. customseparated
  3. dry with materialdried over magnesium sulfate
  4. customThere was obtained a yield of 7.2 g

Sources & evidence

ORD record
ord-03e16e5df3384af19b1f6c2fed634a6c
Source dataset
uspto-grants-1984_11
Patent number
US04483706

Reaction notes

Loading…