HCID 13453446, compound → HCID 13453448, compound

HRID 1979910Notes

Reaction equation

HRID 1979910 reaction equation
C([O:3][C:4]([CH:6]([NH:15][C@H:16]([C:18]([N:20]1[CH2:38][CH2:37][CH2:36][C@H:21]1[C:22]([NH:24][C@H:25]([C:33]([OH:35])=[O:34])[CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)=[O:23])=[O:19])[CH3:17])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:5])C>[OH-].[Na+]>[C:4]([CH:6]([NH:15][C@H:16]([C:18]([N:20]1[CH2:38][CH2:37][CH2:36][C@H:21]1[C:22]([NH:24][C@H:25]([C:33]([OH:35])=[O:34])[CH2:26][C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)=[O:23])=[O:19])[CH3:17])[CH2:7][CH2:8][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)([OH:5])=[O:3]

Participants

3

Reactant 1

HCID 13453446HCID 13453446, compound

Product 1

HCID 13453448HCID 13453448, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

A solution of 1.0 millimole of N-(1-Ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-prolyl-L-phenylalanine in 4 ml of 1N NaOH was kept at room temperature for 18 hours. The solution was put on a column of 300 ml of Dowex 50 (H+) resin. After washing with 500 ml water, the product was eluted with 3% aqueous pyridine solution. After concentration of the eluate in vacuo and lyophilization, the N-(1-carboxy-3-phenylpropyl)-L-alanyl-L-prolyl-L-phenylalanine product was obtained as an amorphous solid.

Workup

  1. washAfter washing with 500 ml water
  2. washthe product was eluted with 3% aqueous pyridine solution

Sources & evidence

ORD record
ord-021e3a7a11434430b6b109c54fac133a
Source dataset
uspto-grants-1984_11
Patent number
US04483850

Reaction notes

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