HCID 13453446, compound → HCID 13453448, compound

Participants

Reaction Steps

A solution of 1.0 millimole of N-(1-Ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-prolyl-L-phenylalanine in 4 ml of 1N NaOH was kept at room temperature for 18 hours. The solution was put on a column of 300 ml of Dowex 50 (H+) resin. After washing with 500 ml water, the product was eluted with 3% aqueous pyridine solution. After concentration of the eluate in vacuo and lyophilization, the N-(1-carboxy-3-phenylpropyl)-L-alanyl-L-prolyl-L-phenylalanine product was obtained as an amorphous solid.

Provenance & Evidence