Hydrogen Bromide → HCID 20437732, compound

HRID 1979915Notes

Reaction equation

HRID 1979915 reaction equation
Cl.C(O[C:10]([N:12]([CH2:14][C:15]1[NH:16][CH2:17][CH2:18][N:19]=1)C)=O)C1C=CC=CC=1.[BrH:20]>C(O)(=O)C.CCOCC>[BrH:20].[BrH:20].[CH3:10][NH:12][CH2:14][C:15]1[NH:19][CH2:18][CH2:17][N:16]=1

Participants

5

Reactant 2

HCID 260Hydrogen BromideHCID 20437737HCID 20437737, compound

Product 1

HCID 20437732HCID 20437732, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolvent2×HCID 3283Diethyl EtherSolvent

Procedure

A solution of 4,5-dihydro-2-(N-benzyloxycarbonyl-N-methylaminomethyl)imidazole hydrochloride (2.0 g) in 2 ml glacial acetic acid was added dropwise to 10 ml of a 30% solution of HBr in acetic acid. After stirring 0.5 hour the reaction was diluted gradually with 15 ml of ether. The mixture was then stirred 24 hours at ambient temperature. The product separated as a white solid which was collected on a filter, washed with ether, and dried. The yield was 1.97 g, m.p. 181°-183° C.

Workup

  1. stirringThe mixture was then stirred 24 hours at ambient temperature
  2. customThe product separated as a white solid which
  3. customwas collected on a filter
  4. washwashed with ether
  5. customdried

Sources & evidence

ORD record
ord-ed015ce4ab99469c909038f956927400
Source dataset
uspto-grants-1984_11
Patent number
US04483858

Reaction notes

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