Acetic Anhydride → HCID 13363150, compound

HRID 1979989Notes

Reaction equation

HRID 1979989 reaction equation
[OH:1][CH2:2][CH2:3][C:4]1[C:5]2[N:6]([N:17]=[CH:18][N:19]=2)[C:7]([NH2:16])=[N:8][C:9]=1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[C:20](OC(=O)C)(=[O:22])[CH3:21]>N1C=CC=CC=1>[C:20]([O:1][CH2:2][CH2:3][C:4]1[C:5]2[N:6]([N:17]=[CH:18][N:19]=2)[C:7]([NH2:16])=[N:8][C:9]=1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(=[O:22])[CH3:21]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 175635Sc-36741

Product 1

HCID 13363150HCID 13363150, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of 25.5 g (0.1 mole) of the title compound of Example 1 and 11 ml (ca. 0.11 mole) of acetic anhydride in 150 ml of pyridine was allowed to stand for about 16 hours at room temperature. Approximately half of the solution was separated and concentrated in vacuo to dryness and chromatographed on silica gel, giving the title compound, m.p. 181°-182°.

Workup

  1. customApproximately half of the solution was separated
  2. concentrationconcentrated in vacuo to dryness
  3. customchromatographed on silica gel

Sources & evidence

ORD record
ord-6c8fae4b4c4b4f4aa7d0c8e2b3756b74
Source dataset
uspto-grants-1984_11
Patent number
US04483987

Reaction notes

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