Pivaloyl chloride → HCID 13363153, compound

HRID 1979991Notes

Reaction equation

[OH:1][CH2:2][CH2:3][C:4]1[C:5]2[N:6]([N:17]=[CH:18][N:19]=2)[C:7]([NH2:16])=[N:8][C:9]=1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[CH3:20][C:21]([CH3:26])([CH3:25])[C:22](Cl)=[O:23]>>[CH3:20][C:21]([CH3:26])([CH3:25])[C:22]([O:1][CH2:2][CH2:3][C:4]1[C:5]2[N:6]([N:17]=[CH:18][N:19]=2)[C:7]([NH2:16])=[N:8][C:9]=1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:23]

Participants

Reactant 2

HCID 62493Pivaloyl chloride

HCID 175635Sc-36741

Product 1

HCID 13363153HCID 13363153, compound

Procedure

The title compound, m.p. 160°, was prepared by the method of Example 2 using 2.5 g (0.01 mole) of the product compound of Example 1 and 1.3 g (0.01 mole) of trimethylacetyl chloride, except that the reaction mixture was poured into 150 ml of water, giving a solid precipitate. Recrystallization from ethyl acetate/diethyl ether, rather than chromatography, afforded the title product.

Sources & evidence

ORD record: ord-48ad07d80831482089082357ca44772e
Source dataset: uspto-grants-1984_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04483987

Reaction notes

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