1-Octene, 7-methoxy-3,7-dimethyl- → HCID 178494943, compound

HRID 1980012Notes

Reaction equation

HRID 1980012 reaction equation
[CH:1]([Mg:4][Cl:5])(C)[CH3:2].[CH3:6][O:7][C:8]([CH3:17])([CH3:16])[CH2:9][CH2:10][CH2:11][CH:12](C)[CH:13]=C>O1CCCC1>[CH3:6][O:7][C:8]([CH3:17])([CH3:16])[CH2:9][CH2:10][CH2:11][CH:12]([CH3:13])[CH2:2][CH2:1][Mg:4][Cl:5]

Participants

4

Reactant 2

HCID 1038251-Octene, 7-methoxy-3,7-dimethyl-HCID 178418918HCID 178418918, compound

Product 1

HCID 178494943HCID 178494943, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

i-Propylmagnesium chloride (0.5 mol) in tetrahydrofuran (200 ml) was treated with 7-methoxy-3,7-dimethyl-1-octene (85 g), followed by dropwise addition of a tri-isobutyl vanadate (7.0 g) in tetrahydrofuran (40 ml) at room temperature. The reaction mixture was then refluxed under nitrogen for 5 h when an aliquot showed a 72% conversion and 87% theoretical yield of the Grignard reagent.

Workup

  1. temperatureThe reaction mixture was then refluxed under nitrogen for 5 h when an aliquot

Sources & evidence

ORD record
ord-fda1d4b7432b49f3bd5d8d0f2625a3b9
Source dataset
uspto-grants-1984_11
Patent number
US04484007

Reaction notes

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