Hydrochloric Acid → HCID 22821046, compound

HRID 1980045Notes

Reaction equation

HRID 1980045 reaction equation
[ClH:1].C(OC([NH:9][CH2:10][C:11]([NH:13][C@H:14]([C:22]([NH:24][CH3:25])=[O:23])[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:12])=O)(C)(C)C>CO>[ClH:1].[NH2:9][CH2:10][C:11]([NH:13][C@H:14]([C:22]([NH:24][CH3:25])=[O:23])[CH2:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)=[O:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13057009HCID 13057009, compound

Product 1

HCID 22821046HCID 22821046, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Gaseous HCl is bubbled through a solution of t-boc-gly-phe-NHCH3 8a (9.2 g, 2.7×10-2 mole) and methanol (200 ml). After 1/2 hour the methanol is evaporated at reduced pressure leaving a clear colorless oil which, when triturated with Et2O crystallizes to give 9a as a colorless power: m.p. 220°-223° C. In a similar fashion, gly-phe-leu-NHEt.HCl is prepared from its corresponding t-boc-derivative.

Workup

  1. customAfter 1/2 hour the methanol is evaporated at reduced pressure
  2. customleaving a clear colorless oil which, when
  3. customtriturated with Et2O
  4. customcrystallizes

Sources & evidence

ORD record
ord-092f773bbc72439db5c8ee5ab65c07f2
Source dataset
uspto-grants-1984_11
Patent number
US04483988

Reaction notes

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