Anisole → HCID 13363415, compound

HRID 1980096Notes

Reaction equation

HRID 1980096 reaction equation
[C:1]1([O:7][CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.FC(F)(F)C1C=C([C:17]23[CH2:26][CH:21]([O:22][C:23]2([CH3:25])[CH3:24])[N:20]([CH3:27])[CH2:19][CH2:18]3)C=CC=1>CC(C)=O>[CH3:8][O:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:17]1([C:23]([CH3:25])([CH3:24])[OH:22])[CH2:26][CH2:21][N:20]([CH3:27])[CH2:19][CH2:18]1

Participants

4

Reactant 2

HCID 7519AnisoleHCID 13363400HCID 13363400, compound

Product 1

HCID 13363415HCID 13363415, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

4-(2'-Methoxyphenyl)-α,α,1-trimethyl-4-piperidinemethanol was prepared from anisole by the procedure described in Example 3 except that acetone was used in place of cyclopentanone in the preparation of III; m.p. 110°-111°; NMR (in CDCl3): τ2.6-3.1 (m, 4H); 6.2 (s, 3H); 6.7-8.5 (m, 9H); 7.9 (s, 3H) and 8.9 (broad s, 6H). Anal. Calcd. for C16H25NO2 : C, 72.96; H, 9.57; N, 5.32. Found: C, 73.02; H, 9.56; N, 5.41.

Sources & evidence

ORD record
ord-8668ea8da3da4255bbe25b1c61879b77
Source dataset
uspto-grants-1984_11
Patent number
US04485109

Reaction notes

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