1,4-Dimethoxybenzene → HCID 13363429, compound

HRID 1980098Notes

Reaction equation

HRID 1980098 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][CH:4]=1.FC(F)(F)C1C=C([C:19]23[CH2:28][CH:23]([O:24][C:25]2([CH3:27])[CH3:26])[N:22]([CH3:29])[CH2:21][CH2:20]3)C=CC=1>CC(C)=O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[C:19]1([C:25]([CH3:27])([CH3:26])[OH:24])[CH2:28][CH2:23][N:22]([CH3:29])[CH2:21][CH2:20]1

Participants

4

Reactant 2

HCID 90161,4-DimethoxybenzeneHCID 13363400HCID 13363400, compound

Product 1

HCID 13363429HCID 13363429, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

4-(2',5'-Dimethoxyphenyl)-α,α,1-trimethyl-4-piperidinemethanol was prepared from 1,4-dimethoxybenzene by the procedure described in Example 3 except that acetone was used in place of cyclopentanone in the synthesis of III; m.p. 139°-140°; NMR (in CDCl3): τ 3.0-3.3 (m, 3H); 6.2 (2s, 6H); 6.6-8.5 (m+s, 12H) and 8.9 (broad, 6H). Anal. Calcd. for C17H27NO3 : C, 69.59; H, 9.29; N, 4.77. Found: C, 69.66; H, 9.09; N, 4.66.

Sources & evidence

ORD record
ord-1d9d9d66ba054ea083bfcffde47d233c
Source dataset
uspto-grants-1984_11
Patent number
US04485109

Reaction notes

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