1,4-Dimethoxybenzene → HCID 13363429, compound

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Reaction Steps

4-(2',5'-Dimethoxyphenyl)-α,α,1-trimethyl-4-piperidinemethanol was prepared from 1,4-dimethoxybenzene by the procedure described in Example 3 except that acetone was used in place of cyclopentanone in the synthesis of III; m.p. 139°-140°; NMR (in CDCl3): τ 3.0-3.3 (m, 3H); 6.2 (2s, 6H); 6.6-8.5 (m+s, 12H) and 8.9 (broad, 6H). Anal. Calcd. for C17H27NO3 : C, 69.59; H, 9.29; N, 4.77. Found: C, 69.66; H, 9.09; N, 4.66.

Provenance & Evidence