5-Bromo-2-chloroisopropylbenzene → HCID 68561612, compound

HRID 19801Notes

Reaction equation

HRID 19801 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[C:4]([CH:9]([CH3:11])[CH3:10])[CH:3]=1.[C:12]([C:16]1[CH:29]=[CH:28][C:19]([CH2:20][N:21]2[CH2:25][CH2:24]OS2(=O)=O)=[CH:18][CH:17]=1)([CH3:15])([CH3:14])[CH3:13]>>[C:12]([C:16]1[CH:17]=[CH:18][C:19]([CH2:20][NH:21][CH2:25][CH2:24][C:2]2[CH:7]=[CH:6][C:5]([Cl:8])=[C:4]([CH:9]([CH3:11])[CH3:10])[CH:3]=2)=[CH:28][CH:29]=1)([CH3:14])([CH3:13])[CH3:15]

Participants

3

Reactant 2

HCID 509978695-Bromo-2-chloroisopropylbenzeneHCID 866139913-(4-Tert-butylbenzyl)-[1,2,3]oxathiazolidine 2,2-dioxide

Product 1

HCID 68561612HCID 68561612, compoundYield 42.2%

Procedure

The title compound was synthesized in analogy to example S6-C using 4-bromo-1-chloro-2-isopropylbenzene (120 mg, 0.51 mmol), and 3-(4-tert-butylbenzyl)-[1,2,3]oxathiazolidine 2,2-dioxide (138 mg, 0.51 mmol). The residue was purified by flash column chromatography to give the desired product (74 mg, 42%) as a light yellow oil. MS (ISP) 344.3 (M+H)+.

Workup

  1. customThe residue was purified by flash column chromatography

Sources & evidence

ORD record
ord-cedd3c82bee5421996ebad9f7280c1c8
Source dataset
uspto-grants-2010_06
Patent number
US07745477B2

Reaction notes

Loading…