10578-09-3 → HCID 178463684, compound

Participants

Reaction Steps

143 g of 6-carboxymethyl-4-hydroxy-1,3,3a,7-tetraazaindene prepared in Synthesis Example 1 and 98 g of vinylbenzylamine were dissolved in 1 l of dimethylformamide with stirring at room temperature. To the solution, 152 g of N,N-dicyclohexylcarbodiimide was added dropwise. After addition, the mixture was stirred at room temperature for 6 hours to separate white crystals (N,N-dicyclohexylurea). After the reaction, the separated crystals were filtered off and the filtrate was poured into 2 l of water to separate white crystals. The separated crystals were filtered out and recrystallized from acetonitrile to obtain 180 g of the desired 4-hydroxy-6-(N-vinylbenzylcarbamoylmethyl)-1,3,3a,7-tetraazaindene.

Provenance & Evidence