Dichloromethane → HCID 23673789, compound

HRID 1980174Notes

Reaction equation

HRID 1980174 reaction equation
C(Cl)Cl.FC(F)(F)C([N:8]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])[C:9]1[CH:17]=[CH:16][C:12]([C:13](Cl)=[O:14])=[CH:11][CH:10]=1)=O.[S:36]([OH:46])(=[O:45])([C:38]1[CH:43]=[CH:42][C:41]([NH2:44])=[CH:40][CH:39]=1)=[O:37].[OH-].[Na+:48]>>[CH2:18]([NH:8][C:9]1[CH:10]=[CH:11][C:12]([C:13]([NH:44][C:41]2[CH:42]=[CH:43][C:38]([S:36]([O-:46])(=[O:37])=[O:45])=[CH:39][CH:40]=2)=[O:14])=[CH:16][CH:17]=1)[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33].[Na+:48]

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8479Sulfanilic acidHCID 14798Sodium HydroxideHCID 20437337HCID 20437337, compound

Product 1

HCID 23673789HCID 23673789, compound

Conditions

Temperature
60 °C

Procedure

A methylene chloride solution of N-trifluoroacetyl-4-(hexadecylamino)benzoyl chloride (4.8 g.) is added to a solution of 1.8 g. of sulfanilic acid in 1N sodium hydroxide at 0° C. After 3 hours, the solution is warmed to 60° C. briefly and the whole evaporated to dryness. The residue is extracted with a small amount of cold water and the resulting white solid crystallized from aqueous ethanol.

Workup

  1. customat 0° C
  2. customthe whole evaporated to dryness
  3. extractionThe residue is extracted with a small amount of cold water
  4. customthe resulting white solid crystallized from aqueous ethanol

Sources & evidence

ORD record
ord-65dd4cb50c5744f7b01eb032a70eadbd
Source dataset
uspto-grants-1984_11
Patent number
US04485105

Reaction notes

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