Formaldehyde → HCID 20402431, compound

HRID 1980237Notes

Reaction equation

HRID 1980237 reaction equation
[CH:1]([NH:4][CH:5]([CH3:11])[CH2:6][O:7][CH:8]([OH:10])[CH3:9])([CH3:3])[CH3:2].[CH2:12]=O>[Pd].CO>[CH:1]([N:4]([CH:5]([CH3:11])[CH2:6][O:7][CH:8]([OH:10])[CH3:9])[CH3:12])([CH3:3])[CH3:2]

Participants

5

Reactant 2

HCID 712FormaldehydeHCID 86739038HCID 86739038, compound

Product 1

HCID 20402431HCID 20402431, compoundYield 94.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Conditions

Temperature
80 °C

Procedure

A total of 155 g of 2-(isopropylamino)propoxyethanol, 122 g of 37% aqueous formaldehyde, 5 g of 10% Pd/C and 1 l of methanol were charged to an autoclave, pressured to 1000 psi with H2 and heated at 80° C. for 3 hours. Filtration and distillation of the reaction mixture yielded 159 g of 2-(N-isopropyl-N-methylamino)propoxyethanol with b.p. of 125° C. at 20 mm.

Workup

  1. filtrationFiltration and distillation of the reaction mixture

Sources & evidence

ORD record
ord-f3de4fd0c7274c51b8149d271ab4d692
Source dataset
uspto-grants-1985_04
Patent number
US04508692

Reaction notes

Loading…