Methane → HCID 20402691, compound

HRID 1980262Notes

Reaction equation

HRID 1980262 reaction equation
Cl.[NH2:2][C:3]1[C:4]([C:9](=[O:16])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[C:5]([CH3:8])[NH:6][CH:7]=1.C.[Cl:18][CH2:19][C:20](Cl)=[O:21].[OH-].[Na+]>O>[C:9]([C:4]1[C:3]([NH:2][C:20](=[O:21])[CH2:19][Cl:18])=[CH:7][NH:6][C:5]=1[CH3:8])(=[O:16])[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

6

Reactant 4

HCID 297MethaneHCID 6577Chloroacetyl chlorideHCID 14798Sodium HydroxideHCID 3042146Methanone, (4-amino-2-methyl-1H-pyrrol-3-yl)phenyl-, monohydrochloride

Product 1

HCID 20402691HCID 20402691, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

4-Amino-3-benzoyl-2-methylpyrrole hydrochloride (0.019 mole) was dissolved in water (40 ml) and the solution was treated with charcoal (0.1 g) and filtered. Toluene was added and chloroacetylchloride (0.067 mole) and aqueous NaOH (58.1 ml, 20% w/v) were added separately but simultaneously during 1 hour to the stirred two-phase solution. The reaction mixture was maintained under an inert atmosphere and at room temperature for 1.5 hour. The compound of the title which spontaneously crystallized out of the reaction mixture, was collected by filtration.

Workup

  1. filtrationfiltered
  2. additionToluene was added
  3. customThe compound of the title which spontaneously crystallized out of the reaction mixture
  4. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-501609bdceec4c06a5f8c4e9e7c1323c
Source dataset
uspto-grants-1985_04
Patent number
US04508730

Reaction notes

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